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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN11
All Species:
10
Human Site:
T415
Identified Species:
22
UniProt:
Q06124
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06124
NP_002825.3
597
68436
T415
Q
A
L
L
Q
G
N
T
E
R
T
V
W
Q
Y
Chimpanzee
Pan troglodytes
XP_001164543
512
58884
P343
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
Y414
L
I
R
E
I
W
H
Y
Q
Y
L
S
W
P
D
Dog
Lupus familis
XP_534686
571
65327
L403
Y
T
L
R
E
L
K
L
S
K
V
G
Q
G
N
Cat
Felis silvestris
Mouse
Mus musculus
P35235
597
68442
T415
Q
A
L
L
Q
G
N
T
E
R
T
V
W
Q
Y
Rat
Rattus norvegicus
P41499
597
68440
T415
Q
A
L
L
Q
G
N
T
E
R
T
V
W
Q
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519242
359
41028
H191
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
Chicken
Gallus gallus
Q90687
593
67964
V415
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
Frog
Xenopus laevis
NP_001084076
595
68232
V415
Q
G
N
T
E
R
A
V
W
Q
Y
H
F
K
T
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
L414
T
A
G
C
L
V
G
L
L
K
R
H
S
N
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
L365
P
S
R
V
L
N
F
L
Q
D
V
N
K
K
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.7
54
95.1
N.A.
99.5
98.9
N.A.
59.2
97.6
93.4
N.A.
N.A.
38.5
N.A.
N.A.
51.9
Protein Similarity:
100
85.7
70
95.1
N.A.
99.8
99.5
N.A.
60.1
98.4
95.8
N.A.
N.A.
51.3
N.A.
N.A.
65.8
P-Site Identity:
100
13.3
6.6
6.6
N.A.
100
100
N.A.
0
6.6
6.6
N.A.
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
26.6
20
20
N.A.
100
100
N.A.
6.6
33.3
33.3
N.A.
N.A.
13.3
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
37
0
0
0
0
10
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
0
0
10
10
0
0
0
0
28
% D
% Glu:
0
0
0
10
28
0
10
0
28
0
0
0
0
0
0
% E
% Phe:
0
0
0
10
0
0
10
0
0
0
0
0
19
0
0
% F
% Gly:
0
19
10
0
0
28
10
0
0
0
10
10
0
10
0
% G
% His:
0
0
10
0
0
0
10
10
0
10
0
28
0
0
0
% H
% Ile:
0
10
0
0
10
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
10
0
0
28
10
0
10
19
0
% K
% Leu:
10
10
37
28
28
10
0
28
10
0
10
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
0
19
0
0
10
28
0
0
0
0
19
0
10
10
% N
% Pro:
10
0
0
0
0
0
0
10
0
0
0
0
19
10
0
% P
% Gln:
55
0
0
0
28
0
0
0
19
19
0
0
10
28
10
% Q
% Arg:
0
0
19
10
10
19
0
0
0
28
10
0
0
10
0
% R
% Ser:
10
10
0
0
0
0
0
0
10
0
0
10
10
10
0
% S
% Thr:
10
10
10
19
0
10
10
28
0
0
28
0
0
0
19
% T
% Val:
0
0
0
10
0
19
0
19
0
0
19
37
0
0
10
% V
% Trp:
0
0
0
0
0
10
10
0
19
0
0
0
37
0
0
% W
% Tyr:
10
10
0
0
0
0
0
10
10
10
19
0
0
0
28
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _